Adult elephants are massive and incredible strong and use their size, trunks and tusks to fend off lions.
Rhinos are large and have powerful horns that can be used to fend off lions.
Hippos are known for their aggression and powerful jaws and can be quite dangerous for lions.
In water, crocs can be quite deadly for lions as they are ambush predators and can grab a lion by surprise.
They are known to scavenge lion kills, but they are also rivals to lions for food and territory.
As a pack, they can be quit formidable for a lion to handle as their numbers can be used to fend off a lion.
In a one-on-one encounter, a tiger could give a lion a run for its money because of its size and strength.